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Semax

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Summary

Semax, 80714-61-0, ACTH (4-7)

Semax is a synthetic peptide derived from a fragment of ACTH hormone that has been studied for cognitive and neuroprotective effects. Research has examined its influence on brain-derived neurotrophic factor, neurotransmitter systems, and neuroplasticity. Studies have investigated its effects on cognitive function, attention, and recovery from neurological challenges.

Current Research
  • Cognitive performance and attention
  • Neuroprotection models (including stroke recovery)
  • BDNF and neurotrophic signaling
Identification
CAS
80714-61-0
Formula
C37H51N9O9S
M.W.
813.9 g/mol

Key Research Statistics

Cognitive & Neuroprotective

+85%Stroke Motor RecoveryHuman clinical use — Russian-approved for acute stroke
96Neuroprotective GenesUpregulated within 3 hours of administration post-stroke
5Human RCTsApproved in Russia since the 1990s for stroke + cognitive impairment
BDNF Pathway Activation
Fold increase over baseline (single dose)
mRNA Expression (Exon III)3x
Serotonin Increase1.8x
TrkB Receptor1.6x
BDNF Protein (Hippocampus)1.4x
Brain Research 2006

Need-to-Know

  • Room Temperature (Lyophilized): Up to 3 weeks
  • Refrigerated (Reconstituted): Up to 42 days
  • Frozen (Lyophilized): 24-36 months
  • Reconstitution Solution: Bacteriostatic water, Sterile water
  • Appearance: White powder

Regulatory Status

Not FDA-approvedInvestigationalResearch

Prescription medicine in Russia for stroke recovery and cognitive function. Research phase in US.

Sources: Russian Pharmacopeia

History

1980s
Developed in Russia in 1980s by scientists I.P. Ashmarin and N.F. Myasoedov for stroke and brain injury.
1990s
Tested on 1,300+ people; approved in Russia in 1994 as nasal spray; first described in literature by 1991.
2000s
Used in Russia for stroke, brain injury, and cognitive decline.
2010s
Added to Russia's essential drugs list (2011).
2020s
Research continues on brain protection.

3D Structure

7-amino-acid peptide · 813.9 g/mol

Interactive model
Semax molecule previewExplore 3D Structure

Semax at the Cellular Level

Nootropic neuropeptide

Mechanism
Semax cellular mechanism preview

Semax in the Body

Synthetic ACTH(4-10) analog with Pro-Gly-Pro

Nervous System
Semax in the Body

Research Library

Peer-reviewed studies

From Published Literature

"Semax affects the expression of genes related to the immune and vascular systems in the brain, demonstrating neuroprotective properties during cerebral ischemia."

Peer-reviewed researchersBMC Genomics
Verify on PubMed

Complete Your Protocol

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