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Pinealon

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Summary

Pinealon is a tripeptide studied for its support of brain function and genetic regulation. Research observes how it may modulate gene expression and neuroprotective pathways, and its potential role in cognition and stress response in various models.

Current Research
  • Brain health and neurological function
  • Cognitive performance and mental clarity
  • Neuroprotective pathways and stress adaptation
Identification
CAS
175175-23-2
M.W.
418.4 g/mol

Key Research Statistics

Neuroprotective Tripeptide

3Amino Acids (Glu-Asp-Arg)Ultra-short peptide — crosses blood-brain barrier without carrier molecules
CREBAANAT UpregulationCREB → AANAT → natural melatonin synthesis restoration
Evidence Confidence by Level
Tiered evidence strength
CREB Pathway Mechanism5/5
Animal Evidence4/5
Human Evidence3/5
Khavinson research group
Neuroprotective Effects (Preclinical)
Caspase-3 activity reduction vs occlusion controls
Cortex Reduction48%
Brainstem Reduction24%
Ischemia model studies

Need-to-Know

  • Room Temperature (Lyophilized): 2-4 weeks
  • Refrigerated (Reconstituted): 14-28 days
  • Frozen (Lyophilized): 12+ months
  • Reconstitution Solution: Bacteriostatic water, Sterile water
  • Appearance: White powder

Regulatory Status

Peptide bioregulator used in Russia as pharmaceutical. Research phase in US.

History

1970s
Russian researcher Vladimir Khavinson began peptide research in 1973.
1980s
Continued development of tissue-specific peptides influencing gene expression.
1990s
Created as 3-amino acid peptide targeting the brain.
2000s
Khavinson completed 40 years of peptide research; brain protective effects shown.
2010s
Studies showed it protects brain cells and reduces damage.
2020s
Research continues on brain health; Khavinson passed away in 2024.

3D Structure

418.4 g/mol

Interactive model
Pinealon molecule previewExplore 3D Structure

Pinealon at the Cellular Level

Pineal gland peptide

Mechanism
Pinealon cellular mechanism preview

Pinealon in the Body

Tripeptide bioregulator (Glu-Asp-Arg)

Nervous System
Pinealon in the Body

Research Library

Peer-reviewed studies

From Published Literature

"Research on the tripeptide Pinealon suggests its potential to protect neuronal structures by mitigating oxidative stress and supporting cognitive function in research models."

Arutjunyan et al.International Journal of Clinical and Experimental Medicine
Verify on PubMed