We’re putting the finishing touches on something special — ordering opens soon. Stay tuned.
← Back to Catalog

AOD-9604

AOD-9604 vial frontAOD-9604 vial back
Loading...

Summary

AOD9604, Tyr-hGH fragment, Lipotropin

AOD-9604 is a modified fragment of human growth hormone that has been studied for its effects on fat metabolism. Research examined how it activates fat breakdown pathways in adipose tissue without affecting blood sugar or growth. The compound went through multiple clinical trials before pharmaceutical development concluded in 2007.

Current Research
  • Fat metabolism and adipose tissue signaling
  • Cartilage and joint repair models
  • Metabolic research in obesity
Identification
CAS
221231-10-3
Formula
C78H123N23O22S2
M.W.
1815.1 g/mol

Key Research Statistics

Lipolysis & Metabolic Safety

600+Patients Studied~40,000 patient-weeks across 6 clinical trials — zero serious AEs
GRASFDA Status (2014)Generally Recognized As Safe — highest safety classification
70%Cartilage RegenerationThickness increase in rabbit OA model — emerging use case
Metabolic Selectivity — No Off-Target Effects
What separates AOD from full-length HGH
Fat Oxidation75
IGF-1 Change0
Insulin Change0
Glucose Change0
Thyroid Change0
Clinical & preclinical data
Discontinuation Rate Comparison
AOD-9604 tolerability vs alternatives
AOD-96045%
Semaglutide (GLP-1)5.9%
Tirzepatide (high dose)10%
Cross-trial comparison

Need-to-Know

  • Room Temperature (Lyophilized): 2-4 weeks
  • Refrigerated (Reconstituted): Up to 28 days (do not freeze reconstituted)
  • Frozen (Lyophilized): 12+ months
  • Reconstitution Solution: Bacteriostatic water
  • Appearance: White powder

Regulatory Status

Not FDA-approvedInvestigationalPhase 2

Under FDA PCAC review for compounding consideration. Phase 2 clinical trials completed.

Sources: FDA.gov, ClinicalTrials.gov

History

1990s
Discovered by Professor Frank Ng at Monash University (Australia) as a small piece of growth hormone that burns fat without affecting blood sugar.
2000s
Tested on 900+ people for obesity treatment; showed weight loss in animal studies.
2010s
Banned by anti-doping agencies as performance enhancer.
2020s
Still banned; available through research suppliers.

3D Structure

16-amino-acid peptide · 1815.1 g/mol

Interactive model
AOD-9604 molecule previewExplore 3D Structure

AOD-9604 at the Cellular Level

HGH fragment 177-191

Mechanism
AOD-9604 cellular mechanism preview

AOD-9604 in the Body

HGH fragment (amino acids 177-191)

Metabolic
AOD-9604 in the Body

Research Library

Peer-reviewed studies

From Published Literature

"AOD9604 showed metabolic effects similar to those of intact hGH with respect to energy balance and fat oxidation, without inducing insulin resistance."

Peer-reviewed researchersPharmacotherapy Review
Verify on PubMed

Complete Your Protocol

Complementary compounds from other research areas