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MOTS-c

MOTS-c vial frontMOTS-c vial back
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Summary

Mitochondrial ORF of the 12S rRNA-c

MOTS-c is a peptide that your mitochondria (cellular power plants) naturally produce, which has been studied for its role in metabolism and energy regulation. Animal research has examined its effects on insulin sensitivity, glucose metabolism, and exercise capacity. Studies have investigated how it influences gene expression and cellular signaling under metabolic stress.

Current Research
  • Mitochondrial function and metabolism
  • Insulin sensitivity research
  • Cardiovascular and healthy-aging biomarkers
Identification
CAS
1627580-64-6
Formula
C101H152N28O21S2
M.W.
2174.6 g/mol

Key Research Statistics

Metabolic & Exercise Mimetic

2xRunning TimeDoubled exercise capacity in aged mice
11.9xMuscle Expression Post-ExerciseNatural MOTS-c surge after physical activity — endogenous signal
AMPKMaster Metabolic SwitchActivates the body's central energy sensor — exercise in a vial
Evidence Confidence by Benefit
Insulin Sensitivity5/5
Physical Performance5/5
Metabolic Improvement5/5
Fat Browning4/5
Mitochondrial Biogenesis4/5
Lee 2015, Kim 2018, Reynolds 2021

Need-to-Know

  • Room Temperature (Lyophilized): 2-3 weeks
  • Refrigerated (Reconstituted): 14-28 days
  • Frozen (Lyophilized): 24+ months
  • Reconstitution Solution: Bacteriostatic water, Sterile water
  • Appearance: White powder

Regulatory Status

Not FDA-approvedInvestigationalPreclinical

Mitochondrial-derived peptide in early clinical research for metabolic function.

Sources: FDA.gov, PubMed

History

2010s
Discovered in 2015 by Dr. Pinchas Cohen and Dr. Changhan Lee at USC; first metabolism peptide made by mitochondria (cell powerhouses); published in Cell Metabolism.
2020s
Studies on longevity and metabolism; linked to healthy aging in some populations.

3D Structure

16-amino-acid peptide · 2174.6 g/mol

Interactive model
MOTS-c molecule previewExplore 3D Structure

MOTS-c at the Cellular Level

Mitochondrial-derived peptide

Mechanism
MOTS-c cellular mechanism preview

MOTS-c in the Body

Mitochondrial-derived peptide

Metabolic
MOTS-c in the Body

Research Library

Peer-reviewed studies

From Published Literature

"MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis, acting as an exercise mimetic."

Peer-reviewed researchersNature Communications
Verify on PubMed

Complete Your Protocol

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