We’re putting the finishing touches on something special — ordering opens soon. Stay tuned.
← Back to Catalog

Melanotan-2

Melanotan-2 vial frontMelanotan-2 vial back
Loading...

Summary

Melanotan II, Bremelanotide, PT-141

Melanotan-2 is a synthetic peptide that activates multiple melanocortin receptors involved in pigmentation, appetite, and other functions. Research has examined its effects on melanin production, food intake, and various physiological responses. Studies have characterized it as more potent and longer-lasting than its analogue Melanotan-1.

Current Research
  • Melanocortin receptor pharmacology
  • Pigmentation and appetite regulation
  • Safety pharmacology and adverse-event research
Identification
CAS
121062-08-6
Formula
C48H69N14O9
M.W.
1024.2 g/mol

Key Research Statistics

Melanogenesis & Melanocortin Activation

41 minRigidity Durationvs 3 min placebo (P=0.0045) — MC4R-mediated
100%Melanin IncreaseTanning without UV exposure — active group
4Melanocortin ReceptorsBroad agonist at MC1R, MC3R, MC4R, MC5R — pigment, libido, and metabolic pathways.
Erectile Response in ED Patients (RCT)
Barnetson 2006 — double-blind, placebo-controlled
Melanotan II85%
Placebo15%
Barnetson 2006 (n=77)

Need-to-Know

  • Room Temperature (Lyophilized): Up to 3 weeks
  • Refrigerated (Reconstituted): Up to 42 days
  • Frozen (Lyophilized): 12+ months
  • Reconstitution Solution: Bacteriostatic water, Sterile water
  • Appearance: White powder

Regulatory Status

Not FDA-approvedResearch OnlyResearch

Melanocortin receptor agonist. Related compound approved for specific indication.

Sources: FDA.gov

History

1990s
Created at University of Arizona for tanning; caused unexpected sexual side effects in animal tests (1996).
2000s
Banned in sports; widely sold online despite no approval.
2010s
Warnings issued about unlicensed use; banned in US and UK.
2020s
Still banned and unapproved; used underground for tanning.

3D Structure

7-amino-acid peptide · 1024.2 g/mol

Interactive model
Melanotan-2 molecule previewExplore 3D Structure

Melanotan-2 at the Cellular Level

Non-selective melanocortin agonist

Mechanism
Melanotan-2 cellular mechanism preview

Melanotan-2 in the Body

Cyclic non-selective melanocortin agonist

Dermal
Melanotan-2 in the Body

Research Library

Peer-reviewed studies

From Published Literature

"Melanotan II stimulates melanocytes in the skin via MC1-R to increase eumelanin production, resulting in enhanced skin pigmentation."

Peer-reviewed researchersDrug Testing and Analysis
Verify on PubMed

Complete Your Protocol

Complementary compounds from other research areas