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5-Amino-1MQ

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Summary

5-amino-1-methylquinolinium, NNMTi

5-Amino-1MQ is a small molecule that blocks an enzyme called NNMT, which plays a role in how cells use energy and store fat. Scientists have studied it in overweight mice and observed changes in body weight and fat tissue. Research has focused on understanding how NNMT inhibition affects metabolism at the cellular level.

Current Research
  • Metabolic regulation and body composition
  • Cellular energy balance (NNMT / NAD+ salvage pathway)
  • Muscle aging and regeneration
Identification
CAS
42464-96-0
Formula
C10H11N2
M.W.
159.2 g/mol

Key Research Statistics

NNMT Inhibition & Body Recomposition

1.6xNAD+ IncreaseIntracellular levels — by blocking the NNMT drain
11 daysTo Reverse Obesity PhenotypeDiet-induced obese mice — body weight, fat mass, and metabolic markers normalized. Preclinical.
Preclinical Metabolic Effects
Diet-induced obese mice, 11 days
Glucose Tolerance ↑70%
Insulin Sensitivity ↑65%
Hepatic Steatosis ↓60%
Adipocyte Lipogenesis ↓50%
Fat Mass ↓35%
Cholesterol ↓30%
Neelakantan 2018
Grip Strength in Aged Mice
8 weeks, 10 mg/kg/day — exercise synergy
5A1MQ + Exercise60%
5A1MQ Alone40%
Exercise Alone20%
Dimet-Wiley 2024

Need-to-Know

  • Room Temperature (Lyophilized): 2-4 weeks
  • Refrigerated (Reconstituted): 14-30 days
  • Frozen (Lyophilized): 12-24 months
  • Reconstitution Solution: Bacteriostatic water, Sterile water
  • Appearance: Orange powder

Regulatory Status

Not FDA-approvedInvestigationalPreclinical

NNMT inhibitor in early preclinical research for metabolic regulation.

Sources: FDA.gov, PubMed

History

2010s
Research showed it helped mice lose weight by blocking an enzyme that slows metabolism.
2020s
Studies found it reduced body fat and cholesterol in animal models; became popular for fat loss.

3D Structure

Small molecule · 159.2 g/mol

Interactive model
5-Amino-1MQ molecule previewExplore 3D Structure

5-Amino-1MQ at the Cellular Level

NNMT inhibitor

Mechanism
5-Amino-1MQ cellular mechanism preview

5-Amino-1MQ in the Body

NNMT enzyme inhibitor

Metabolic
5-Amino-1MQ in the Body

Research Library

Peer-reviewed studies

From Published Literature

"Treatment with 5-amino-1MQ produced concentration-dependent inhibition of lipid accumulation, reducing lipogenesis by 50% and reversing diet-induced obesity in mice."

Peer-reviewed researchersBiochemical Pharmacology
Verify on PubMed

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