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Selank

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Summary

TP-7, Selanc

Selank is a synthetic peptide that has been studied for its effects on anxiety and cognitive function. Research has examined how it influences brain-derived neurotrophic factor expression and neurotransmitter systems. Studies have investigated its effects on anxiety symptoms and mental performance in various research settings.

Current Research
  • Anxiety and stress-response research
  • Cognitive performance and memory
  • BDNF and neurotransmitter modulation
Identification
CAS
129954-34-3
Formula
C33H57N11O8
M.W.
751.9 g/mol

Key Research Statistics

Anxiolytic & Cognitive Enhancement

92.8%Intranasal BioavailabilityNear-complete nasal absorption — no injection required
0Dependence RiskNo sedation, amnesia, tolerance, or withdrawal — unlike benzodiazepines
Hamilton Anxiety Scale (Human Study)
2700 µg/day intranasal — rapid vs conventional responders
Baseline20.3
Rapid (Day 3)7
Conventional (Day 14)6.2
Koroleva 2019 (n=20)
Anxiolytic Effect — Benzodiazepine Comparison
Comparable efficacy, no dependence risk
Selank — No Dependence90
Medazepam — Addictive95
Frontiers in Pharmacology 2016

Need-to-Know

  • Room Temperature (Lyophilized): Up to 3 weeks
  • Refrigerated (Reconstituted): Up to 42 days
  • Frozen (Lyophilized): 24-36 months
  • Reconstitution Solution: Bacteriostatic water, Sterile water
  • Appearance: White powder

Regulatory Status

Not FDA-approvedInvestigationalResearch

Prescription medicine in Russia for anxiety and cognitive support. Research phase in US.

Sources: Russian Pharmacopeia

History

1990s
Designed at Institute of Molecular Genetics (Russian Academy of Sciences) in 1990s as synthetic anxiety-reducing peptide.
2000s
Approved in Russia in 2009 for anxiety and brain function.
2010s
Available in Russia and Ukraine; ongoing brain chemistry research.
2020s
Still used in Russia; not evaluated in Western countries.

3D Structure

7-amino-acid peptide · 751.9 g/mol

Interactive model
Selank molecule previewExplore 3D Structure

Selank at the Cellular Level

Anxiolytic neuropeptide

Mechanism
Selank cellular mechanism preview

Selank in the Body

Synthetic tuftsin analog with anxiolytic properties

Nervous System
Selank in the Body

Research Library

Peer-reviewed studies

From Published Literature

"Clinical studies showed that the effect of Selank is similar to that of tranquilizers, but without the unwanted side effects such as amnesia, withdrawal, and dependence."

Peer-reviewed researchersRegulatory Peptides
Verify on PubMed